General description
Immunoglobulin A (IgA) plays a critical role in mucosal immunity. It is present in the mucosal secretions such as tears, saliva, colostrum, intestinal juice, vaginal fluid, and secretions from the prostate and respiratory epithelium, and represents a key first line of defense against invasion by inhaled and ingested pathogens at the vulnerable mucosal surfaces. It is also found in small amounts in blood. Because it is resistant to degradation by enzymes, secretory IgA can survive in harsh environments such as the digestive and respiratory tracts, to provide protection against microbes that multiply in body secretions. It is useful when identifying multiple myeloma and plasmacytomas.1-3
Legal Information
Cell Marque is a trademark of Sigma-Aldrich Co. LLC
Linkage
IgA (polyclonal) Positive Control Slides, Product No. 267S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
Other Notes
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Physical form
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and ﹤0.1% Sodium Azide.
Preparation Note
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Quality
This product has met the following criteria to qualify for the following awards: