Clodronate; Disodium Salt

Biochem/physiol Actions

Cell permeable: no

Reversible: no

Product does not compete with ATP.

Primary TargetOsteoclast-mediated bone resorption

Target IC₅₀: 100 nM inhibiting invasion, adhesion, and migration of PC-3 prostate cancer cells

General description

A non-amino, chloro-containing bisphosphonate that acts as a potent inhibitor of osteoclast-mediated bone resorption. It is metabolized into a non-hydrolyzable ATP analog in osteoclasts and macrophages, and induces apoptosis by inhibiting mitochondrial function. An efficient metal chelator that inhibits invasion, adhesion, and migration of PC-3 prostate cancer cells (IC₅₀ = 100 nM).

A non-amino, chloro-containing, bisphosphonate that acts as a potent inhibitor of osteoclast-mediated bone resorption. Metabolized to a non-hydrolyzable ATP analog in osteoclasts and macrophages that induces apoptosis by inhibiting mitochondrial function. An efficient metal chelator that inhibits invasion, adhesion and migration of PC-3 prostate cancer cells (IC₅₀ = 100 nM).

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Lehenkari, P.P., et al. 2002. Mol. Pharmacol.61, 1255.Virtanen, S.S., et al. 2002. Cancer Res.62, 2708.Smith, R., et al. 1971. Lancet1, 945.Fleisch, H., et al. 1969. Nature223, 211.

Packaging

10 mg in Plastic ampoule

Warning

Toxicity: Standard Handling (A)