Cathepsin G Inhibitor I

Biochem/physiol Actions

Cell permeable: no

Reversible: yes

Primary Targetcathepsin G

Product does not compete with ATP.

Target K_i: 63 nM for cathepsin G

General description

A potent, selective, reversible, competitive, non-peptide inhibitor of cathepsin G [IC₅₀ = 53 nM and K_i = 63 nM]. Weakly inhibits chymotrypsin (K_i = 1.5 µM) and poorly inhibits thrombin, factor Xa, factor IXa, plasmin, trypsin, tryptase, proteinase 3, and human leukocyte elastase (IC₅₀ >100 µM).

A potent, selective, reversible, and competitive non-peptide inhibitor of cathepsin G (IC₅₀ = 53 nM and K_i = 63 nM). Weakly inhibits chymotrypsin (K_i = 1.5 µM) and does not have any significant inhibitory effect on thrombin, factor Xa, factor IXa, plasmin, trypsin, tryptase, proteinase 3, and human leukocyte elastase (IC₅₀ >100 µM).

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Greco, M.N., et al. 2002. J. Am. Chem. Soc.124, 3810.

Packaging

1 mg in Plastic ampoule

5 mg in Glass bottle

Packaged under inert gas

Reconstitution

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Warning

Toxicity: Standard Handling (A)