Cdc25 Inhibitor IV; NSC 95397

General description

A cell-permeable, para-naphthoquinone that has been reported to inhibit protein tyrosine phosphatase activity, including Cdc25 dual specificity phosphatase (K_i = 32 nM, 96 nM, and 40 nM for Cdc25A, -B, and -C, respectively) and blocks G₂M transition in murine carcinoma cells. In addition, it is shown to inhibit S100A4 binding to myosin-IIA via covalent modification of cysteine residues, Cys81 and Cys86, in the target binding cleft (IC₅₀ = 1.8 µM). It demonstrates inhibitory activity against S100A4-mediated depolymerization of myosin-IIA filaments.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Dulyaninova, N.G., et al. 2011. Biochemistry50, 7218.Lazo, J.S., et al. 2002. Mol. Pharmacol.61, 720.

Packaging

Packaged under inert gas

10 mg in Glass bottle

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Warning

Toxicity: Standard Handling (A)