Biochem/physiol Actions

Target IC₅₀: 17 µM inhibiting calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase

Product does not compete with ATP.

Primary TargetCalmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase

General description

Inhibits calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase (IC₅₀ = 17 µM). Acts as a peripheral vasodilator. Acts as an inhibitor of lysosomal sphingomyelinase and of TNF-α production. Inhibits nitric oxide synthase (NOS) in mouse brain and prevents lipopolysaccharide induction of NOS in murine lung. Shown to potently and specifically inhibit KSP/Eg5 (IC₅₀﹤10 µM), and PLA2.

Inhibits calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase (IC₅₀ = 17 µM). Acts as a peripheral vasodilator. An inhibitor of TNFα production. Inhibits nitric oxide synthase (NOS) in mouse brain and prevents lipopolysaccharide induction of NOS in murine lung. Shown to potently and specifically inhibit KSP/Eg5 (IC₅₀﹤10 µM), and PLA2.

Inhibits calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase (IC₅₀ = 17 µM).

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Lee, M.S., et al. 2007. Cancer Res.67, 11359.Maor, I., et al. 1995. Arteriosclero. Thromb. Vasc. Biol. 15, 1378.Netea, M.G., et al. 1995. J. Infect. Dis. 171, 393.Lindahl, M., and Tagesson, C. 1993. Inflammation17, 573.Palacios, M., et al. 1993. Biochem. Biophys. Res. Commun. 196, 280.Yamamoto, H. 1993. Toxicol. Lett. 66, 73.Vadas, P., et al. 1986. Agents Actions19, 194. Marshak, P.R., et al. 1985. Biochemistry24, 144.

Packaging

500 mg in Alu drum

Reconstitution

Following reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 6 months at -20°C and for up to 1 week at 4°C.

Warning

Toxicity: Toxic (F)