Cyclo(Arg-Gly-Asp-D-Phe-Val)

Biochem/physiol Actions

Cell permeable: no

Reversible: no

Primary Targetinhibits tumor cell adhesion to laminin and vitronectin substrates

Product does not compete with ATP.

General description

Potent inhibitor of cell adhesion. Inhibits tumor cell adhesion to laminin and vitronectin substrates. In vivo investigations in rats showed it to be useful in the amelioration of ischemic acute renal failure in rats. Also inhibits tubular obstruction by preventing cell-cell adhesion. Inhibits the redistribution of c-Src into focal adhesions, thereby leading to impaired MAP Kinase activation.

Potent inhibitor of cell adhesion. Inhibits tumor cell adhesion to laminin and vitronectin substrates. In vivo investigations showed it to be useful in the amelioration of ischemic acute renal failure in rats. Also inhibits tubular obstruction by preventing cell-cell adhesion.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Shono, T., et al. 2001. Exp. Cell Res.268, 169.Matsuno, H., et al. 1994. Circulation 90, 2203.Noiri, E., et al. 1994. Kidney Int. 46, 1050.Gurrath, M., et al. 1992. Eur. J. Biochem. 210, 911.

Packaging

1 mg in Plastic ampoule

Warning

Toxicity: Standard Handling (A)