(+)-Bicuculline, >=97.0% (TLC)

Code: 14340-500MG D2-231

Application

Bicuculline has been used: as a compound to compare pharmacodynamics and network activity profiles of conolidine/cannabidiolto study the effects of chronic caffei...


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€343.69 500MG
€422.74 inc. VAT
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Application

Bicuculline has been used: as a compound to compare pharmacodynamics and network activity profiles of conolidine/cannabidiolto study the effects of chronic caffeine administration on the function of GABAA receptorto isolate N-methyl-D-aspartate receptor (NMDAR)-specific evoked and miniature excitatory postsynaptic currents (eEPSCs and mEPSCs) in neurons of rats

Biochem/physiol Actions

(+)-Bicuculline is a GABAA receptor antagonist.

(+)-Bicuculline acts as a competitive inhibitor of GABA liganding binding to the receptor.

Features and Benefits

This compound is featured on the GABAC Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

General description

Bicuculline is a convulsant alkaloid. It was originally isolated from the plant Dicentra cucullaria.

assay≥97.0% (TLC)
formpowder
Gene Informationrat ... Gabra2(29706)
InChI keyIYGYMKDQCDOMRE-ZWKOTPCHSA-N
InChI1S/C20H17NO6/c1-21-5-4-10-6-14-15(25-8-24-14)7-12(10)17(21)18-11-2-3-13-19(26-9-23-13)16(11)20(22)27-18/h2-3,6-7,17-18H,4-5,8-9H2,1H3/t17-,18+/m0/s1
mp193-197 °C
optical activity[α]20/D +126±6°, c = 1% in chloroform
Quality Level100
SMILES string[H][C@]1(OC(=O)c2c3OCOc3ccc12)[C@@]4([H])N(C)CCc5cc6OCOc6cc45
Cas Number485-49-4
This product has met the following criteria to qualify for the following awards:



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