General description

Anti-CD8 is a T-cell marker for the detection of cytotoxic/suppressor lymphocytes. CD8 is also detected on NK cells, most thymocytes, a subpopulation of null cells and bone marrow cells. This antibody, along with other markers, can be used to distinguish between reactive and neoplastic T-cells. Expression of both CD4 (+) and CD8 (+), or lack of expression of both markers in a lymphoid population would be evidence for lymphoma. Although most T-cell lymphoma/leukemias can be either CD8+ or CD8-, CD8 positivity is a factor against Mycosis Fungoides as this entity is negative for CD8. Rarely does anti-CD8 label non-hematolymphoid neoplasms.

Legal Information

Cell Marque is a trademark of Sigma-Aldrich Co. LLC

Linkage

CD8 Positive Control Slides, Product No. 108S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Other Notes

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Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and ﹤0.1% Sodium Azide

Preparation Note

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