Analysis Note

Single spot by TLC

Biochem/physiol Actions

Cell permeable: no

Reversible: no

Target IC₅₀: 10 µM as a selective antagonist of farnesoid X receptor (FXR) and inhibits FXR transactivation in the presence of 100 µM chenodeoxycholic acid

Product does not compete with ATP.

Primary TargetFarnesoid X receptor (FXR)

General description

A synthetic form of the guggul tree plant steroid that exhibits an ability to lower LDL cholesterol and triglyceride levels. Acts as a selective antagonist of farnesoid X receptor (FXR) and inhibits FXR transactivation (IC₅₀ = 10 µM in the presence of 100 µM chenodeoxycholic acid). Does not activate or inhibit transactivation of liver X receptor α (LXRα), peroxisome proliferator activated receptor γ (PPARγ), or retinoid X receptor α (RXRα).

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Cui, J., et al. 2003. J. Biol. Chem.278, 10214.Urizar, N.L., et al. 2002. Science296, 1703; Chander, R., et al. 1996. Phytotherapy Res.10, 508.

Packaging

Packaged under inert gas

10, 25 mg in Plastic ampoule

Reconstitution

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Warning

Toxicity: Standard Handling (A)