alpha-DHED

Code: SML2396-25MG D2-231

Biochem/physiol Actions

α-DHED is a bioprecursor prodrug of 17α-estradiol ((Alfatradiol)) that results in 17α-estradiol being produced selectively in the brain...


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Biochem/physiol Actions

α-DHED is a bioprecursor prodrug of 17α-estradiol ((Alfatradiol)) that results in 17α-estradiol being produced selectively in the brain with little production in the periphery. α-DHED has no estrogenic activity itself with little affinity for either ERα and ERβ estrogen receptors. 17α-estradiol (αE2) has been proposed to have potential roles in various neurodegenerative disorders including neuroprotection of the brain and the prevention/treatment of Alzheimer’;s disease, but peripheral side-effects on estrogen-sensitive organs have been problematic. α-DHED, a prodrug without estrogenic activity, could help alleviate those concerns.

assay≥98% (HPLC)
colorwhite to beige
formpowder
SMILES stringO[C@@]12C(CC[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@H]4O)=CC(C=C1)=O
solubilityDMSO: 2 mg/mL, clear
storage temp.2-8°C
Cas Number2362514-18-7
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