YM-26734

Code: SML1226-25MG D2-231

Biochem/physiol Actions

YM-26734 is a competitive inhibitor of the secreted (Group II) form of phospholipase A2. The IC50 against rabbit platelet derived sPLA2 is ...


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€452.40 25MG
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Biochem/physiol Actions

YM-26734 is a competitive inhibitor of the secreted (Group II) form of phospholipase A2. The IC50 against rabbit platelet derived sPLA2 is 85 nM. YM-26734 is active against, but less potent for group I (pancreatic) sPLA2 (porcine pancreatic enzyme IC50 = 7 µM), and does not inhibit intracellular PLA2 isoforms.

YM-26734 is a natural product analog and a derivative of YM-26567-1, which is found in the fruit ofHorsfieldia amygdaline. It exhibits a broad inhibitory spectrum towards different sPLA2s.

Packaging

5, 25 mg in glass bottle

assay≥95% (HPLC)
colorwhite to beige
formpowder
InChI keyCEJAYJCUSZHYDS-UHFFFAOYSA-N
InChI1S/C45H62O8/c1-3-5-7-9-11-13-15-17-19-21-36(48)41-43(50)40(44(51)42(45(41)52)37(49)22-20-18-16-14-12-10-8-6-4-2)35-30-38(31-23-25-32(46)26-24-31)53-39-29-33(47)27-28-34(35)39/h23-29,35,38,46-47,50-52H,3-22,30H2,1-2H3
Quality Level100
SMILES stringOC1=C(C2CC(C3=CC=C(O)C=C3)OC4=C2C=CC(O)=C4)C(O)=C(C(CCCCCCCCCCC)=O)C(O)=C1C(CCCCCCCCCCC)=O
solubilityDMSO: 20 mg/mL, clear
storage temp.−20°C
Cas Number144337-18-8
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