Biochem/physiol Actions

Primary TargetN-WASP (neural Wiskott Aldrich syndrome protein)

Reversible: yes

Product does not compete with ATP.

Cell permeable: yes

General description

A cell-permeable N-alkylated carbazole derivative that selectively blocks actin filament assembly. Acts as a selective, reversible inhibitor of neural Wiskott Aldrich Syndrome protein (N-WASP). Reported to bind to N-WASP, stabilize the auto-inhibited conformation, and prevent the activation of actin-related protein 2/3 (Arp2/3) complex.

A cell-permeable N-alkylated carbazole derivative that selectively blocks actin filament assembly. Acts as a selective, reversible inhibitor of N-WASP (neural Wiskott Aldrich syndrome protein), a signal integrating protein. Appears to bind to N-WASP, stabilize the autoinhibited conformation and prevent the activation of Arp2/3 (actin-related protein 2/3) complex.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Peterson, J.R., et al. 2004. Nat. Struct. Mol. Biol.11, 747.Peterson, J.R., and Mitchison, T.J. 2002. Chem. Biol.9, 1275.

Packaging

1, 5 mg in Plastic ampoule

Packaged under inert gas

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Warning

Toxicity: Standard Handling (A)