VX-745

Code: SML1638-25MG D2-231

Biochem/physiol Actions

VX-745 is a selective blood-brain barrier penetrant inhibitor of p38 MAPKα. VX-745 showed 20-fold selectivity for p38α over p38β and a ...


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€375.80 25MG
€462.23 inc. VAT
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Biochem/physiol Actions

VX-745 is a selective blood-brain barrier penetrant inhibitor of p38 MAPKα. VX-745 showed 20-fold selectivity for p38α over p38β and a Ki value of 220 nM. VX-745 has been shown to reduce inflammation in an arthritic (AIA) mouse model and to improve performance in aged rats.

Other Notes

VX-745 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the VX-745 probe summary on the Chemical Probes Portal website.

Packaging

5, 25 mg in glass bottle

assay≥98% (HPLC)
colorwhite to beige
formpowder
Gene Informationhuman ... MAPK14(1432)
InChI keyVEPKQEUBKLEPRA-UHFFFAOYSA-N
InChI1S/C19H9Cl2F2N3OS/c20-11-2-1-3-12(21)17(11)18-14-5-7-16(25-26(14)9-24-19(18)27)28-15-6-4-10(22)8-13(15)23/h1-9H
Quality Level100
SMILES stringFC1=C(SC2=NN(C=N3)C(C=C2)=C(C4=C(Cl)C=CC=C4Cl)C3=O)C=CC(F)=C1
solubilityDMSO: 10 mg/mL, clear
storage temp.−20°C
Cas Number209410-46-8
This product has met the following criteria to qualify for the following awards:



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