ULBP2HUMAN

Code: SRP6348-100UG D2-231

General description

ULBP2, also known as NKG2D ligand 2, belongs to the MHC class I family. This protein is ligand for the NKG2D receptor, together with at least ULBP1 and UL...


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€578.85 100UG
Discontinued
€711.99 inc. VAT

General description

ULBP2, also known as NKG2D ligand 2, belongs to the MHC class I family. This protein is ligand for the NKG2D receptor, together with at least ULBP1 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP2 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface. Recombinant human ULBP2 protein, fused to His-tag at N-terminus, was expressed in E.coli.

Physical form

1 mg/mL in 20 mM Tris-HCl buffer (pH 8.0) containing 0.2 M NaCl, 30% glycerol, 2 M Urea and 2 mM DTT.

assay≥85% (SDS-PAGE)
biological sourcehuman
concentration1 mg/mL
formliquid
Gene Informationhuman ... ULBP2(80328)
mol wt24.3 kDa (216 aa, 26-216 aa + His Tag)
packagingpkg of 100 µg
recombinantexpressed in E. coli
shipped indry ice
storage temp.−70°C
UniProt accession no.Q9BZM5 
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