Biochem/physiol Actions

Cell permeable: no

Reversible: no

Shown to inhibit the activity of Isopeptidase T (catNO=419700">Cat. No. 419700) and Ubiquitin C-Terminal Hydrolase (catNO=662090">Cat. No. 662090)

Product does not compete with ATP.

Primary Targetmultiple ubiquitin hydrolases involved in pathways of intracellular protein modification and turnover

General description

Potent and specific inhibitor of multiple ubiquitin hydrolases involved in pathways of intracellular protein modification and turnover. Useful for stabilizing endogenous or in vitro synthesized ubiquitin-protein conjugates. May also be used to enhance or decrease the rates of ubiquitin-dependent degradation.

Potent and specific inhibitor of multiple ubiquitin hydrolases involved in pathways of intracellular protein modification and turnover. Useful for stabilizing endogenous or in vitro synthesized ubiquitin-protein conjugates. May also be used to enhance or decrease rates of ubiquitin-dependent degradation.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Melandri, F., et al. 1996. Biochemistry 35, 12893.Shaeffer, J.R. and Cohen, R.E. 1996. Biochemistry 35, 10886.Pickart, C.M. and Rose, I.A. 1986. J. Biol. Chem. 261, 10210.

Packaging

50 µg in Plastic ampoule

Please refer to vial label for lot-specific concentration.

Physical form

In 150 mM HCL.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C).

Warning

Toxicity: Standard Handling (A)