Biochem/physiol Actions

Target IC₅₀: 4 µM inhibiting cellular fatty acid synthesis in human breast cancer cell line MCF7

Reversible: yes

Product competes with ATP.

Cell permeable: yes

Primary TargetAcetyl-CoA carboxylase (ACC)

General description

A cell-permeable furoic acid compound that acts as a potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in the fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner (IC₅₀ = 4 µM in human breast cancer cell line MCF7). TOFA-induced reduction in malonyl-CoA is reported to off-set the effect of C75 (Cat. No. 341325) on food intake in fasted mice and on apoptosis in tumor cells.

A cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner (IC₅₀ = 4 µM in human breast cancer cell line MCF7). TOFA-induced reduction in malonyl-CoA is reported to off-set the effects of C75 (Cat. No. 341325) on food intake in fasted mice and on apoptosis in tumor cells.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Landree, L.E., et al. 2004. J. Biol. Chem.279, 3817.Zhou, W., et al. 2003. Cancer Res.63, 7330.Hu, Z., et al. 2003. Proc. Natl. Acad. Sci. USA100, 12624.Pizer, E.S., et al. 2000. Cancer Res.60, 213.Arbeeny, C.M., et al. 1992. J. Lipid Res.33, 843.Fukuda, N. and Ontko, J.A. 1984. J. Lipid Res.25, 831.

Packaging

Packaged under inert gas

5 mg in Plastic ampoule

Preparation Note

Slight warming and sonication may be required for complete solubilization in ethanol.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Warning

Toxicity: Carcinogenic / Teratogenic (D)