TNCA

Code: SML1711-10MG D2-231

Biochem/physiol Actions

TNCA is a tryptophan derivative that binds the parathyroid Ca2+-sensing receptor (CaSR) extracellular domain (ECD) hinge region between two...


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€68.40 10MG
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Biochem/physiol Actions

TNCA is a tryptophan derivative that binds the parathyroid Ca2+-sensing receptor (CaSR) extracellular domain (ECD) hinge region between two globular subdomains and acts as a high-affinity CaSR ligand (CaSRL) with co-agonist activity. TNCA is shown to potentiate both Mg++- and Ca++-evoked cellular calcium response (0.1-0.5 mM), as well as Mg++-evoked cellular ERK1/2 phosphorylation in CaSR-expressing HEK293 cells (0.5 mM). AC-265347 (Cat. No. SML0129), on the other hand, is a calcimimetic that functions as a CaSR agonist.

Packaging

10, 50 mg in glass bottle

assay≥98% (HPLC)
colorwhite to beige
formpowder
InChI keyFSNCEEGOMTYXKY-JTQLQIEISA-N
InChI1S/C12H12N2O2/c15-12(16)10-5-8-7-3-1-2-4-9(7)14-11(8)6-13-10/h1-4,10,13-14H,5-6H2,(H,15,16)/t10-/m0/s1
optical activity[α]/D -57 to -67°, c = 1 (in MeOH:1N HCl (1:1))
Quality Level100
SMILES stringO=C(O)[C@H]1NCC2=C(C3=C(N2)C=CC=C3)C1
solubility1.5 mg/mL, clear (Solvent: 0.1N HCl:DMSO (1:1); warmed)
storage temp.−20°C
Cas Number42438-90-4
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