Biochem/physiol Actions
Reversible: no
Product does not compete with ATP.
Primary TargetFree radical scavenger and nitric oxide spin trap
Cell permeable: yes
General description
A stable, cell-permeable nitroxide that acts as a free radical scavenger and nitric oxide spin trap. Induces oxidative stress and enhances the levels of p21WAF1 in HL-60 cells in a dose-dependent manner. Reported to reduce organ injury following hemorrhagic shock. Exhibits radio-protective and anti-proliferative properties.
A stable, cell-permeable nitroxide free radical that acts as a radical scavenger and nitric oxide spin trap. Induces oxidative stress and enhances the levels of p21WAF1 in HL-60 cells in a dose-dependent manner. Reported to reduce organ injury following hemorrhagic shock. Exhibits radio-protective and anti-proliferative properties.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
Gariboldi, M.B., et al. 2000. Free Radic. Biol. Med.29, 633.Miura, Y., et al. 2000. J. Radiat. Res. (Tokyo)41, 103.Mota-Filipe, H., et al. 1999. Shock 12, 255.
Packaging
Packaged under inert gas
500 mg in Plastic ampoule
Reconstitution
Prepare fresh solutions. Following reconstitution, aliquot and freeze (-20°C).
Warning
Toxicity: Harmful (C)
This product has met the following criteria to qualify for the following awards: