Biochem/physiol Actions

Primary TargetNMDA receptors

General description

A negative allosteric modulator selective for NR2A containing NMDA receptors (pIC₅₀ = 6.8 and ﹤4.3 µM for NR2A and NR2B, respectively). No effect on NR2B-containing NMDA receptors with concentrations less than 50 mM. Inhibition on NR2A containing NMDA receptors is glycine (or D-serine)-binding, but not glutamate-binding, dependent.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Bettini. E., et al. 2010. J. Pharm. Exp. Ther.335, 644.Shin, A., et al. 2011. Br. J. Pharmacol.166, 1002.Edman, S., et al. 2012. Neuropharmacology63, 441.Hansen, K., et al. 2012. J. Neurosci.32, 6197.

Packaging

5 mg in Glass bottle

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Warning

Toxicity: Standard Handling (A)