Biochem/physiol Actions

Cell permeable: no

Reversible: no

Primary TargetTNF-α converting enzyme/ADAM17

Product does not compete with ATP.

Target IC₅₀: 100 nM against TACE (TNF-α converting enzyme/ADAM17)

General description

A hydroxymate-based inhibitor of collagenase, gelatinase, and TACE [(TNF-α convertase; ADAM17 (IC₅₀ = 100 nM)]. Blocks spontaneous and PMA-induced release of TNF-α from transfected COS-7 cells.

A hydroxamate-based inhibitor of collagenase, gelatinase, and TACE (TNF-α converting enzyme/ADAM17; IC₅₀ = 100 nM). Blocks spontaneous and PMA-induced release of TNF-α in transfected COS 7 cells.

Legal Information

Manufactured exclusively by Peptides International, Louisville, Kentucky, USA.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Hooper, N.M., et al. 1997. Biochem. J.321, 265.Mullberg, J., et al. 1995. J. Immunol.155, 5198.Mohler, K.M., et al. 1994. Nature370, 218.

Packaging

1 mg in Plastic ampoule

Packaged under inert gas

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

Warning

Toxicity: Standard Handling (A)