Biochem/physiol Actions

Reversible: no

Product does not compete with ATP.

Primary Targetβ-tubulin

Cell permeable: yes

General description

A cell-permeable pentafluorosulfonamide compound that covalently binds to β-tubulin and induces microtubule depolymerization and cell-cycle arrest by irreversibly modifying β-tubulin. T113242-induced activation of gene transcription has been shown to be mediated by the Erk signaling pathway and the transcription factor MIZ-1 (myc-interacting zinc finger protein).

A cell-permeable pentafluorosulfonamide compound that induces microtubule depolymerization and cell-cycle arrest by irreversibly modifying β-tubulin. T113242-induced activation of gene transcriptions has been shown to be mediated by Erk signalling pathway and the transcription factor MIZ-1 (myc-interacting zinc finger protein).

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Ziegelbauer, J., et al. 2004. Proc. Natl. Acad. Sci. USA101, 458.Ziegelbauer, J., et al. 2001. Mol. Cell8, 339.

Packaging

Packaged under inert gas

10 mg in Plastic ampoule

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Warning

Toxicity: Carcinogenic / Teratogenic (D)