Biochem/physiol Actions

Reversible: no

Product does not compete with ATP.

Primary TargetLiver X receptor (LXRα)

Cell permeable: yes

EC50 = 20 nM for LXRα

General description

A cell-permeable, nonsterol, benzenesulfonamide compound that acts as a highly selective and potent liver X receptor agonist (EC₅₀ = 20 nM for LXRα). Reported to induce the expression of genes associated with fatty acid biosynthesis. Raises the levels of serum HDL cholesterol and triglycerides in mice and inhibits the development of atherosclerosis in LDL receptor-deficient mice. Also shown to lower plasma glucose levels in diabetic rodents.

A cell-permeable, nonsterol, benzenesulfonamide compound that acts as a highly selective and potent liver X receptor agonist (EC₅₀ of 20 nM for LXR_α). Reported to induce the expression of genes associated with fatty acid biosynthesis and raise both the levels of serum HDL cholesterol and triglyceride in mice. Also reduces the development of atherosclerosis in LDL receptor-deficient mice and lowers plasma glucose in diabetic rodents.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Terasaka, N., et al. 2003. FEBS Lett.536, 6.Cao, G., et al. 2002. J. Biol. Chem.278, 1131.Field, F.J., et al. 2002. Biochem. J.368, 855.Fukumoto, H., et al. 2002. J. Biol. Chem.277, 48508.DeBose-Boyd, R.A., et al. 2001. Proc. Natl. Acad. Sci. USA98, 1477.Repa, J.J., et al. 2000. Science289, 1524.Schultz, J.R., et al. 2000. Genes Dev.14, 2831.

Packaging

Packaged under inert gas

10 mg in Plastic ampoule

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Warning

Toxicity: Harmful (C)