Biochem/physiol Actions

Reversible: no

Primary TargetBlocker of Stat3 activation

Product does not compete with ATP.

Cell permeable: yes

General description

A cell-permeable analog of the Stat3-SH2 domain-binding phospho-peptide (Cat. No. 573095) that contains a C-terminal membrane translocating sequence (MTS) and acts as a highly selective, potent blocker of Stat3 activation. Also suppresses constitutive Stat3-dependent Src transformation with no effect on Stat3-independent Ras transformation.

Supplied as a trifluoroacetate salt.

A cell-permeable analog of the Stat3-SH2 domain-binding phosphopeptide (Cat. No. 573095) that contains a C-terminal mts (membrane translocating sequence) and acts as a highly selective, potent blocker of Stat3 activation. Also suppresses constitutive Stat-3 dependent Src transformation with no effect on Stat-3 independent Ras transformation. The unphosphorylated inactive control peptide is also available under Cat. No. 573105.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Turkson, J., et al. 2001. J. Biol. Chem.276, 45443.Rojas, M., et al. 1998. Nat. Biotechnol.16, 370.

Packaging

1, 5 mg in Plastic ampoule

Packaged under inert gas

Sequence

H-Pro-Tyr-(PO₃H₂)-Leu-Lys-Thr-Lys-Ala-Ala-Val-Leu-Leu-Pro-Val-Leu-Leu-Ala-Ala-Pro-OH

Warning

Toxicity: Standard Handling (A)