Biochem/physiol Actions

Reversible: yes

General description

D₂-like dopamine receptor antagonist targeting D₂R (pKi =8.0), D₃R (pKi = 7.9), and 5-HT1A R (pKi=5.2). Used to explore D₂ like receptor mediated effects in neuropathic pain, and in antagonism studies of DA receptors during heroin usage and cocaine. D₂ Receptor selectivity in various preps shows IC₅₀ values around 32 nM.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Dang, Y. H. et al. 2010. Neurosci.169, 1872.r>Platt, D. M. et al. 2010. J. Pharmacol. Exp. Ther.332, 985.

Packaging

10 mg in Glass bottle

Warning

Toxicity: Standard Handling (A)