Biochem/physiol Actions

Reversible: no

Target IC₅₀: 2 µM against PDE IV

Product does not compete with ATP.

Cell permeable: yes

Primary TargetPDE IV

General description

Selective inhibitor of cAMP-specific phosphodiesterase (PDE IV, IC₅₀ = 2 µM). Inhibits superoxide generation and arachidonic-induced platelet aggregation. Also inhibits fMLP-induced neutrophil adhesion to vascular endothelial cells.

A cell-permeable, selective inhibitor of cAMP-specific phosphodiesterase (PDE IV; IC₅₀ = 2 µM). Inhibits superoxide generation and arachidonic-induced platelet aggregation. Also inhibits fMLP-induced neutrophil adhesion to vascular endothelial cells.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Derian, C.K., et al. 1995. J. Immunol. 154, 308.Rubin, L.L., et al. 1991. J. Cell Biol.115, 1725.Lad, P.M., et al. 1985. Biochim. Biophys. Acta 846, 286.Bergstrand, H., et al. 1977. Mol. Pharmacol.13, 38.

Packaging

100 mg in Plastic ampoule

Warning

Toxicity: Irritant (B)