ROMIDEPSIN

Code: SML1175-1MG D2-231

Biochem/physiol Actions

Romidepsin promotes apoptosis, while hindering tumor growth in glioma models.

Romidepsin is a very potent natural prodrug inhibitor of HDAC1 and...


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€345.80 1MG
€425.33 inc. VAT
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Biochem/physiol Actions

Romidepsin promotes apoptosis, while hindering tumor growth in glioma models.

Romidepsin is a very potent natural prodrug inhibitor of HDAC1 and HDAC2 that is converted to active form by glutathione. Romidepsin has IC50 values of 36 nM and 47 nM for HDAC1 and HDAC2, respectively. Romidepsin kills lymphoma cell lines overexpressing Bcl-2 and Bcl-XL, and has been approved for the treatment for cutaneous T-cell lymphoma (CTCL) and peripheral T-cell lymphoma, and a variety of other cancers.

Packaging

1 mg in glass bottle

assay≥98% (HPLC)
colorwhite to beige
formpowder
Gene Informationhuman ... HDAC1(3065), HDAC10(83933), HDAC11(79885), HDAC2(3066), HDAC3(8841), HDAC4(9759), HDAC5(10014), HDAC6(10013), HDAC7(51564), HDAC8(55869), HDAC9(9734)
InChI keyOHRURASPPZQGQM-GCCNXGTGSA-N
InChI1S/C24H36N4O6S2/c1-6-16-21(30)28-20(14(4)5)24(33)34-15-9-7-8-10-35-36-12-17(22(31)25-16)26-23(32)19(13(2)3)27-18(29)11-15/h6-7,9,13-15,17,19-20H,8,10-12H2,1-5H3,(H,25,31)(H,26,32)(H,27,29)(H,28,30)/b9-7+,16-6-/t15-,17-,19-,20+/m1/s1
Quality Level100
SMILES stringO=C(N/C(C(N[C@@H](C(C)C)C(O[C@@]1([H])CC2=O)=O)=O)=CC)[C@@H](CSSCC/C=C/1)NC([C@H](N2)C(C)C)=O
solubilityDMSO: 25 mg/mL, clear
storage temp.−20°C
Cas Number128517-07-7
This product has met the following criteria to qualify for the following awards:



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