Biochem/physiol Actions
fully active in neurophysiological testing
Cell permeable: no
Reversible: no
Product does not compete with ATP.
Primary TargetA powerful blocker of voltage-sensitive Na+ conductance
General description
A quaternary lidocaine derivative, permanently charged, and lipophobic. A powerful blocker of voltage-sensitive Na+ conductance when applied intracellularly. Suppresses the generation of Na+-dependent spikes from inside the cell membrane, without affecting Ca2+ currents or glutamate-activated currents.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
Mooney, R. 1992. J. Neurosci.12, 2464.Regehr, W.G. and Tank, D.W. 1992. J. Neurosci.12, 4202.
Packaging
100 mg in Plastic ampoule
Warning
Toxicity: Irritant (B)
This product has met the following criteria to qualify for the following awards: