Biochem/physiol Actions

Reversible: no

Product does not compete with ATP.

Target IC₅₀: 20-50 µM against protein kinase C

Cell permeable: yes

General description

A cell-permeable inhibtor of protein kinase C (IC₅₀ = 20-50 µM). Activates Ca²⁺-activated K⁺ channels in amphibian myelinated nerve fibers at micromolar concentrations. An inhibitor of myo-inositol uptake. Also inhibits L-type Ca²⁺ channel activity. A potent inhibitor of 5′-iodothyronine deiodinase. Antagonist of prostaglandin F_2α receptors linked to phospholipase C in astrocytes.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Berry, G.T., et al. 1994. Pediat. Res.35, 141.Koh, D.S., et al. 1994. Neurosci. Lett. 165, 167.Morreale de Escobar, G., et al. 1994. Endocrinology134, 2410.Prevarskaya, N., et al. 1994. Mol. Cell. Neurosci.5, 699.Kitanaka, J., et al. 1993. J. Neurochem.60, 704.Wang, X., et al. 1993. Biochem. J.290, 249.Benga, G., et al. 1992. Eur. J. Cell Biol.59, 219.Jordan, M.L., and Wright, J. 1991. J. Surg. Res.50, 569.

Packaging

200 mg in Plastic ampoule

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Ethanol stock solutions are stable for up to 1 month at -20°C.

Warning

Toxicity: Irritant (B)