Application

Prostaglandin A1(PGA1) has been used to activate Ca²⁺ channel of human sperm (CatSper).

Biochem/physiol Actions

Prostaglandins (PG) mediates various physiological functions and the action of blood vessels. PGA1 also inhibits viral replication and promotes heat shock protein (HSP) expression, exhibiting neuroprotection. PGA1 is known to relieve cellular stress.

Prostaglandin A1 (PGA1) boosts the expression of human liver-specific cytochrome P450 4F3B (CYP4F3B) and stimulates the synthesis of 20-hydroxy-eicosatetraenoic acids (HETEs). It has an ability to stimulate cell differentiation, ferritin synthesis and heat shock response in human cells. PGA1 exhibits antitumor and antiviral activities. In addition, it also elicits anti-inflammatory effects by activating peroxisome proliferator-activated receptor (PPAR). Elevated levels of PGA1 has been observed in hypertension patients.

General description

Prostaglandins (PG) are hormones present in many tissues and organs. They are long chain polyunsaturated fatty acids. PGA1 is a cyclopentenone molecule.

Prostaglandin A1(PGA1) belongs to the class of cyclopentenone prostaglandin. PGA1 is generated by the dehydration of prostaglandin E1 (PGE1).

Packaging

5 mL Amber Glass Screw Cap Vial (900115P-1mg)