CL-387;785

Code: 233100-1MG D2-231

Biochem/physiol Actions

Reversible: no

Product does not compete with ATP.

Target IC50: 250-490 pM inhibiting EGF-receptor (EGFR) kinase activity in...


read more

Your Price
€236.10 1MG
€290.40 inc. VAT

Biochem/physiol Actions

Reversible: no

Product does not compete with ATP.

Target IC50: 250-490 pM inhibiting EGF-receptor (EGFR) kinase activity in vivo; 5 nM inhibiting EGF-stimulated autophosphorylation of tyrosine residues in the EGFR in vivo

Cell permeable: yes

Primary TargetEGFR kinase activity

General description

A cell-permeable and irreversible inhibitor of EGF-receptor (EGFR) kinase activity in vivo (IC50 = 250-490 pM) as well as EGF-stimulated autophosphorylation of tyrosine residues in the EGFR in vivo (IC50 = 5 nM). Blocks EGF-mediated growth in A431 cells. Inhibits proliferation of EGFR or c-ErbB2 expressing cells (IC50 = 31-125 nM) by covalently binding to the EGFR.

A cell-permeable and irreversible inhibitor of EGF-stimulated autophosphorylation of tyrosine residues in the epidermal growth factor receptor (EGFR) in vivo (IC50 = 250-490 pM) and blocks EGF-mediated growth. Also inhibits proliferation of cells that overexpress EGFR or c-Erb-2 (IC50 = 31-125 nM) by covalently binding to EGFR.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Sweeney, W.E., et al. 2000. Kidney Int.57, 33.Discafani, C.M., et al. 1999. Biochem. Pharmacol. 57, 917.Sweeney, W.E., et. al. 1999. Kidney Int.56, 406.

Packaging

1 mg in Plastic ampoule

Packaged under inert gas

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

Warning

Toxicity: Standard Handling (A)

assay≥95% (HPLC)
colorpale yellow
formsolid
manufacturer/tradenameCalbiochem®
Quality Level100
shipped inambient
solubilityDMSO: 200 mg/mL
storage conditiondesiccated (hygroscopic), protect from light, OK to freeze
storage temp.−20°C
Cas Number194423-06-8
This product has met the following criteria to qualify for the following awards:



PROCEED TO CHECKOUT

HAVE AN ACCOUNT? LOGIN


GUEST CHECKOUT

Proceed as a guest. You will have the option to register to access exclusive pricing and stock availability features after checkout.