Biochem/physiol Actions

Reversible: no

Primary Targetproton pump

Product does not compete with ATP.

Cell permeable: yes

General description

A cell-permeable pyridyl methylsulfinyl benzimidazole compound that acts as selective proton pump inhibitor. Behaves as a prodrug by undergoing an acid-catalyzed rearrangement to a thiol-reactive cationic sulfenamide that inhibits (H⁺, K⁺)-ATPase in the gastric milieu. An aryl hydrocarbon-like inducer of cytochrome P450 secretion in human liver.

A cell-permeable, selective proton pump inhibitor. Behaves as a prodrug by undergoing an acid-catalyzed rearrangement to a thiol-reactive cationic sulfenamide that inhibits (H⁺-K⁺)-ATPase in the gastric milieu. Also acts as an aryl hydrocarbon-like inducer of cytochrome P450 secretion in human liver.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Lambrecht, N., et al. 2000. J. Biol. Chem.275, 4041.Besancon, M., et al. 1997. J. Biol. Chem.272, 22438.Sachs, G., et al. 1995. Ann. Rev. Pharmacol. Toxicol.35, 277.Diaz, D., et al. 1990. Gastroenterology99, 737.Fellenius, E., et al. 1981. Nature290, 159.

Packaging

Packaged under inert gas

50 mg in Plastic ampoule

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Warning

Toxicity: Irritant (B)