Oligomycin

Biochem/physiol Actions

Cell permeable: no

Reversible: no

Product does not compete with ATP.

Primary TargetMembrane-bound mitochondrial ATPase (F1)

General description

A mixture of A, B, and C isomers. A macrolide antibiotic that inhibits membrane-bound mitochondrial ATP synthase, preventing phosphoryl group transfer. Induces apoptosis in cultured human lymphoblastoid and other mammalian cells.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Wolvetang, E.J., et al. 1994. FEBS Lett.339, 40.Amoroso, S., et al. 1993. J. Pharmacol. Exp. Ther.264, 515.Brustovetsky, N.N., et al. 1993. FEBS Lett.315, 233.Nagamune, H., et al. 1993. Biochim. Biophys. Acta1141, 231.

Packaging

10 mg in Plastic ampoule

Reconstitution

Following reconstitution, aliquot and freeze (-20°C. Stock solutions are stable for up to 2 months at -20°C.

Warning

Toxicity: Irritant (B)