NSC57969

Code: SML1863-5MG D2-231

Biochem/physiol Actions

NSC57969 is a MDR-selective compound that exhibits a robust Pgp-dependent toxic activity across diverse cancer cell lines. NSC57969 shows profound tox...


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€127.40 5MG
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Biochem/physiol Actions

NSC57969 is a MDR-selective compound that exhibits a robust Pgp-dependent toxic activity across diverse cancer cell lines. NSC57969 shows profound toxicity against doxorubicin resistant Brca1-/-;p53-/- spontaneous mouse mammary carcinoma cells. NSC57969 eradicates P-glycoprotein expression in doxorubicin resistant brca1-/-;p53-/- spontaneous mouse mammary carcinoma, and MES-SA/Dx5 cells. However treatment of normal cells (hCMEC/D3 cells) with NSC57969 does not induce loss of Pgp.

Packaging

5, 25 mg in glass bottle

assay≥98% (HPLC)
colorwhite to beige
formpowder
InChI keyWXMFPLZGDXLEMN-UHFFFAOYSA-N
InChI1S/C15H18N2O/c18-15-13(11-17-9-2-1-3-10-17)7-6-12-5-4-8-16-14(12)15/h4-8,18H,1-3,9-11H2
Quality Level100
SMILES stringOC1=C(N=CC=C2)C2=CC=C1CN3CCCCC3
solubilityDMSO: 5 mg/mL, clear (warmed)
storage temp.2-8°C
Cas Number6632-09-3
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