NS3728

Code: SML1964-25MG D2-231

Biochem/physiol Actions

NS3728 (Endovion) is a di-aryl-urea-based reversible anion channel blocker that is shown to inhibit Ca(2+)-independent Cl- conductance by volume-regul...


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€542.00 25MG
Discontinued
€666.66 inc. VAT

Biochem/physiol Actions

NS3728 (Endovion) is a di-aryl-urea-based reversible anion channel blocker that is shown to inhibit Ca(2+)-independent Cl- conductance by volume-regulated anion channel (VRAC or VSOAC; IC50 = 400 nM) as well as Ca2+-activated Cl- ccurrent (CaCC) by anoctamin (ANO) in an apparently voltage-dependent manner (IC50 against ANO1 = 2.1 and 0.7 µM at -95 and +50 mV, respectively). NS3728 is reported to be 5.5-times more potent than Tamoxifen against VRAC (IC50 = 0.4 vs. 2.2 µM).

assay≥98% (HPLC)
colorwhite to beige
formpowder
solubilityDMSO: 10 mg/mL, clear
storage temp.2-8°C
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