Biochem/physiol Actions

Reversible: no

Product does not compete with ATP.

Cell permeable: yes

General description

Cell-permeable superoxide dismutase (SOD) mimetic. Catalyzes the dismutation of O₂^– (rate constant ~4 x 10⁷ M^-1 s^-1) even in the presence of excess EDTA. Can substitute for SOD in mutants of E. coli lacking this enzyme. MnTMPyP acts in vivo as an NADPH/GSH:O₂ oxidoreductase rather than as an SOD mimetic. Also an efficient peroxynitrite reductase when redox-coupled with biological antioxidants.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Izbicka, E., et al. 1999. Cancer Res.59, 639.Lee, J., et al. 1998. J. Am. Chem. Soc. 120, 6053.Gardner, P.R., et al. 1996. Arch. Biochem. Biophys. 325, 20.Liochev, S.I., and Fridovich, I. 1995. Arch. Biochem. Biophys. 321, 271.Faulkner, K.M., et al. 1994. J. Biol. Chem. 269, 23471.

Packaging

25 mg in Plastic ampoule

Warning

Toxicity: Standard Handling (A)