Biochem/physiol Actions

Reversible: no

Product does not compete with ATP.

EC50 ~40 µM in protecting endothelial cells against paraquat (2 mM)

Cell permeable: yes

Primary TargetSuperoxide dismutase (SOD) mimetic

General description

Cell-permeable superoxide dismutase (SOD) mimetic and peroxynitrite scavenger. Protects endothelial cells in a dose-dependent manner (EC₅₀ ~40 µM) against paraquat (2 mM). Inhibits the oxidation of dihydrorhodamine-123 by peroxynitrite, but does not scavenge nitric oxide (NO).

Cell-permeable superoxide dismutase (SOD) mimetic and peroxynitrite scavenger. Protects endothelial cells in a dose-dependent manner (EC₅₀ ~40 µM) against paraquat (2 mM). Inhibits the oxidation of Dihydrorhodamine 123 (Cat. No. 309825) by peroxynitrite, but does not scavenge nitric oxide (NO).

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Aladag, M. A., et al. 2003. Acta Neurochir.145, 673.Szabo, C., et al. 1996. FEBS Lett. 381, 82.Day, B.J., et al. 1995. J. Pharmacol. Exp. Ther. 275, 1227.Faulkner, K.M., et al. 1994. J. Biol. Chem. 269, 23471.

Packaging

25 mg in Plastic ampoule

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Warning

Toxicity: Standard Handling (A)