Biochem/physiol Actions

Target IC₅₀: 300 nM against PDE III

Reversible: no

Product does not compete with ATP.

Cell permeable: yes

Primary TargetPDE 3

General description

A cell-permeable, selective inhibitor of cGMP-inhibited phosphodiesterase (PDE III, IC₅₀ = 300 nM). Has positive chronotropic, ionotropic, and vasodilatory effects on the heart.

A cell-permeable, selective inhibitor of cGMP-inhibited phosphodiesterase (PDE III; IC₅₀ = 300 nM). Has positive chronotropic, inotropic, and vasodilatory effects on the heart.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Bailey, J.M., et al. 1994. Anesthesiology 81, 616.Wilhelm, D., et al. 1992. J. Cardiovasc. Pharmacol.20, 705.Lindgren, S.H., et al. 1990. Acta. Phys. Scand.140, 209.Harrison, S.A., et al. 1986. Mol. Pharmacol.29, 506.

Packaging

10 mg in Alu drum

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.

Warning

Toxicity: Toxic (F)