Biochem/physiol Actions

Primary TargetNMDA receptors

Target IC₅₀: 0.8, 0.57, 0.52, and 0.54 →M for GluN2A, B, C, and D, respectively.

General description

Memantine Hydrochloride is a very potent, voltage-dependent, rapidly unbinding antagonist (calcium channel blocker) of NMDA receptors.

A very potent, voltage-dependent, rapidly unbinding antagonist (calcium channel blocker) of NMDA receptors (IC₅₀ = 0.8, 0.57, 0.52, and 0.54 µM for GluN2A, B, C, and D, respectively). A popular medicine for treating moderate-to-severe Alzheimer′s disease. Frequently used in studying brain functions and disorders involving neurotransmission mediated by NMDA receptors (i.e. learning and memory, cognitive functions, neuroplasticity, Alzheimer′s disease, schizophrenia, bipolar depression, obsessive-compulsive disorders, oxidative stress, and excitotoxicity).

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Limapichat, W., et al. 2012. ACS Chem. Neurosci.4, 255.Anand, A., et al. 2012. Bipolar Dis.14, 64.Lopes, P., et al. 2013. Brain and Behavior.3, 67.Howard, R., et al. 2012. New Eng. J. Med.366, 893.Parsons, G., et al. 1999. Neuropharmacol.38, 735. Lee, G., et al. 2012. Psychiatry Investig.9, 166.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Warning

Toxicity: Standard Handling (A)