Biochem/physiol Actions

Primary TargetGABA_A

General description

A constituent and psychoactive ingredient of the mushroom Amanita muscariathat acts as a potent agonist of GABA_A receptors (EC₅₀ = 28 µM and 33 µM in neonatal and adult rats, respectively), with preferential efficacy and selectivity to high-affinity receptor subtypes. Shown to be permeate the blood-brain barrier. Impairs associate and memory functions.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Chandra, D., et al. 2010. Neuropsychopharmacology.35, 999.Fischer, H., et al. 2005. J. Physiol.564, 465. Ramirez, D.R., et al. 2005. Neurobiol. Learning and Memory.84, 184.

Packaging

1 mg in Glass bottle

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Warning

Toxicity: Toxic (F)