Biochem/physiol Actions

Cell permeable: no

Reversible: no

Primary Targetrat NOS

Product does not compete with ATP.

General description

A hormone that has been postulated as the mediator of photo-induced anti-gonadotropic activity in photoperiodic mammals. Counteracts the apoptotic effects of etoposide in bone marrow cells. Melatonin receptors are coupled to a G-protein system. Exhibits antioxidant properties. Has neuroprotective effects against Aβ peptides. Inhibits rat cerebellar nitric oxide synthase (NOS). Also acts as a peroxynitrite scavenger.

A hormone that has been postulated as being a mediator of photic-induced anti-gonadotropic activity in photoperiodic mammals. Counteracts the apoptotic effects of etoposide in bone marrow cells. Melatonin receptors are coupled to a G-protein system. Inhibits rat cerebellar nitric oxide synthase (NOS).

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Pappolla, M.A., et al. 2002. J. Pineal Res.32, 135.Reiter, R.J., and Tan, D.X. 2002. Ann. N.Y. Acad. Sci.957, 341.Cuzzocrea, S., et al. 1998. J. Pineal Res. 25, 24.Maestroni, G.J., et al. 1994. Cancer Res. 54, 2429.Pozo, D., et al. 1994. Life Sciences55, PL455.

Packaging

1 g in Plastic ampoule

Reconstitution

Following reconstiution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Warning

Toxicity: Standard Handling (A)