Application

MCB-613 has been used to study the molecular mechanism of MCB-613-induced cell death.

Biochem/physiol Actions

MCB-613 is capable of inducing the transcriptional activity of steroid receptor coactivators (SRCs).

MCB-613 is a pan-Steroid Receptor Coactivator (SRC) stimulator. There are three steroid receptor coactivators (SRC) that interact with transcription factors and whose overexpression is assciated with a number of cancers, particularly breast cancer. MCB-613 overstimulates SRC activity in cancer cells resulting in excessive generation of reactive oxygen species (ROS), leading to cell stress and death by a process called paraptosis. MCB-613 is a cytotoxic molecule which can kill various human cancer cell lines, like HepG2 (liver), PC-3 (prostate) and MCF-7 (breast) cells.

General description

MCB-613 (4-Ethyl-2,6-bis-pyridin-3-ylmethylene-cyclohexanone) belongs to the chalcone class of compounds. It is an anti-neoplastic compound.

Packaging

5, 25 mg in glass bottle