Lactimidomycin

Code: 5062910001 D2-231

Biochem/physiol Actions

Reversible: yes

Primary TargetRibosome

General description

A glutarimide based 12-membered macrolide antibiotic wit...


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€426.60 EACH
€524.72 inc. VAT

Biochem/physiol Actions

Reversible: yes

Primary TargetRibosome

General description

A glutarimide based 12-membered macrolide antibiotic with antifungal properties. Acts as a potent inhibitor of cell migration, cell proliferation, and protein synthesis (IC50 = 37.82 nM), but does not affect RNA synthesis even at high concentrations (IC50 >10 µM). Acts as a potent inhibitor of translation and appears to block the first translocation step without affecting tRNA binding or peptide bond formation. It exhibits about 10-fold greater potency than cycloheximide (Cat. No. 239763 and 239764). Binds to the same site on the 60S ribosomal subunit with high affinity (Kd = 500 nM vs 15 µM for cycloheximide). Shown to extend the survival of mice bearing P388 lymphoma by blocking cell growth, however, it does not significantly affect non-tumorigenic MCF10A breast cell lines. Also shown to retard the growth of MDA MB231 cells in nude mice (~0.6 /mg/kg).

Lactimidomycin, CAS 134869-15-1, inhibits cell migration, proliferation, & protein synthesis (IC50 = 37.8 nM). Blocks the first translocation step and has no effect on tRNA binding.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Schneider-Poetsch, T., et al. 2010. Nat. Chem. Biol.6, 209.Micoine, K., et al. 2010. J. Am. Chem. Soc.132, 14064.Ju, J., et al. 2009. J. Am. Chem. Soc.131, 1370.Sugawara, K., et al. 1992. J. Antibiot.45, 1433.

Packaging

0.2 mg in Glass bottle

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Warning

Toxicity: Standard Handling (A)

assay≥98% (HPLC)
colorwhite
formpowder
InChI keyOYOKHBHOTQDIPM-YVQSYIHDSA-N
InChI1S/C26H35NO6/c1-17-10-8-6-4-5-7-9-11-25(32)33-26(17)19(3)12-18(2)22(29)16-21(28)13-20-14-23(30)27-24(31)15-20/h4,6,8-12,17-18,20-21,26,28H,5,7,13-16H2,1-3H3,(H,27,30,31)/b6-4-,10-8-,11-9-,19-12-
manufacturer/tradenameCalbiochem®
potency37.8 nM IC50
Quality Level100
solubilityDMSO: soluble
storage conditionprotect from light, OK to freeze
storage temp.−20°C
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