KU-55933

Code: SML1109-25MG D2-231

Application

KU-55933 has been used as an ataxia-telangiectasia mutated (Atm) inhibitor.

Biochem/physiol Actions

KU-55933 is a very potent, specif...


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€439.00 25MG
€539.97 inc. VAT
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Application

KU-55933 has been used as an ataxia-telangiectasia mutated (Atm) inhibitor.

Biochem/physiol Actions

KU-55933 is a very potent, specific inhibitor of Ataxia telangiectasia (A-T) mutated (ATM) kinase (IC50 = 13 nM). KU-22933 treatment sensitizes cancer cells to ionizing radiation and cytotoxic drugs. The compound KU-22933 blocks ATM-mediated phosphorylyation of p53, gH2AX, NBS1, and SMC1.

Packaging

5, 25 mg in glass bottle

assay≥98% (HPLC)
colorwhite to beige
formpowder
InChI keyXRKYMMUGXMWDAO-UHFFFAOYSA-N
InChI1S/C21H17NO3S2/c23-14-12-16(25-20(13-14)22-8-10-24-11-9-22)15-4-3-7-19-21(15)27-18-6-2-1-5-17(18)26-19/h1-7,12-13H,8-11H2
Quality Level100
SMILES stringO=C1C=C(OC(=C1)c2cccc3Sc4ccccc4Sc23)N5CCOCC5
solubilityDMSO: 10 mg/mL, clear
storage conditiondesiccated
storage temp.−20°C
Cas Number587871-26-9
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