Biochem/physiol Actions

Reversible: yes

Product competes with ATP.

Target K_i: 2 nM, 4 nM and 52 nM for JNK1, 2 and 3, respectively

Cell permeable: yes

General description

A cell-permeable pyridinylamide compound that acts as an ATP-competitive, reversible inhibitor of JNK (K_i = 2 nM, 4 nM and 52 nM for JNK1, 2 and 3, respectively) and displays excellent selectivity over 72 other kinases. Inhibits c-jun phosphorylation with an EC₅₀ of 920 nM in HepG2 cells. Preferentially blocks the growth of PTEN null mouse embryonic fibroblasts.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Vivanco, I., et al. 2007. Cancer Cell11, 555.Szczepankiewicz, B. G., et al. 2006. J. Med. Chem.49, 3563.

Packaging

Packaged under inert gas

5 mg in Plastic ampoule

Warning

Toxicity: Standard Handling (A)