General description

Interferon regulatory factor (IRF) 2 is a member of the interferon regulatory transcription factor family. IRF-2 is generally regarded as an oncoprotein. Structure of IRF1 and IRF2 are similar. However, its functions are different. IRF2 competitively inhibits the IRF1-mediated transcriptional activation of interferons α and β, and presumably other genes that employ IRF1 for transcription activation. Recombinant human IRF2 was expressed in E.coli and purified by using conventional chromatography techniques.

Physical form

1 mg/mL in 20 mM Tris-HCl buffer (pH 8.0), 1 mM DTT and 10% glycerol.