Biochem/physiol Actions

Primary TargetPPARα

Reversible: no

EC50 = 6 nM, 1.1 µM and 6.2 µM for human PPARα, γ and δ, respectively; EC50 = 1 nM, 1.3 µM and 2.9 µM for murine PPARα, γ and δ, respectively

Product does not compete with ATP.

Cell permeable: yes

General description

A cell-permeable urea-substituted thioisobutyric acid (ureido-TiBA) compound that acts as a potent and selective PPARα agonist (PPARα, γ and δ - EC₅₀ = 6 nM, 1.1 µM and 6.2 µM for human; 1 nM, 1.3 µM and 2.9 µM for murine, respectively). Also displays in vivo lipid-lowering activity in rats.

A cell-permeable, urea-substituted, thioisobutyric acid (ureido-TiBA) compound that acts as a potent and selective peroxisome proliferator-activated receptor α (PPARα) agonist (EC₅₀ = 6 nM for human PPARα, 1.1 µM for human PPARγ, and 6.2 µM human PPARδ; 1 nM for murine PPARα, 1.3 µM for murine PPARγ, and 2.9 µM murine PPARδ). Also shown to lower lipid levels in rats.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Muoio, D.M., et al. 2002. J. Biol. Chem.277, 26089.Brown, P.J., et al. 2001. Bioorg. Med. Chem. Lett.11, 1225.Oliver, W.R. Jr., et al. 2001. Proc. Natl. Acad. Sci. USA98, 5306.Poirier, H., et al. 2001. Biochem. J.355, 481.

Packaging

Packaged under inert gas

5 mg in Plastic ampoule

Warning

Toxicity: Irritant (B)