Biochem/physiol Actions
Primary TargetPPARα
Reversible: no
EC50 = 6 nM, 1.1 µM and 6.2 µM for human PPARα, γ and δ, respectively; EC50 = 1 nM, 1.3 µM and 2.9 µM for murine PPARα, γ and δ, respectively
Product does not compete with ATP.
Cell permeable: yes
General description
A cell-permeable urea-substituted thioisobutyric acid (ureido-TiBA) compound that acts as a potent and selective PPARα agonist (PPARα, γ and δ - EC50 = 6 nM, 1.1 µM and 6.2 µM for human; 1 nM, 1.3 µM and 2.9 µM for murine, respectively). Also displays in vivo lipid-lowering activity in rats.
A cell-permeable, urea-substituted, thioisobutyric acid (ureido-TiBA) compound that acts as a potent and selective peroxisome proliferator-activated receptor α (PPARα) agonist (EC50 = 6 nM for human PPARα, 1.1 µM for human PPARγ, and 6.2 µM human PPARδ; 1 nM for murine PPARα, 1.3 µM for murine PPARγ, and 2.9 µM murine PPARδ). Also shown to lower lipid levels in rats.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
Muoio, D.M., et al. 2002. J. Biol. Chem.277, 26089.Brown, P.J., et al. 2001. Bioorg. Med. Chem. Lett.11, 1225.Oliver, W.R. Jr., et al. 2001. Proc. Natl. Acad. Sci. USA98, 5306.Poirier, H., et al. 2001. Biochem. J.355, 481.
Packaging
Packaged under inert gas
5 mg in Plastic ampoule
Warning
Toxicity: Irritant (B)
This product has met the following criteria to qualify for the following awards: