GNF-4877

Code: SML2664-25MG D2-231

Biochem/physiol Actions

GNF-4877 is an orally available dual inhibitor of Dyrk1a and Gsk3b that induces proliferation of functional primary human and rodent β-cells. GNF...


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OVERVIEW

Biochem/physiol Actions

GNF-4877 is an orally available dual inhibitor of Dyrk1a and Gsk3b that induces proliferation of functional primary human and rodent β-cells. GNF4877 reduces non-fasting blood glucose levels in a mouse model of T1D.

SPECIFICATIONS
assay≥98% (HPLC)
colorfaint yellow to dark orange
formpowder
SMILES stringNC1=NC=C(C2=CC(OC(C)C)=CC=C2F)N=C1C(NC3=CN=CC=C3N4C[C@H](C(O)=O)CCC4)=O
solubilityDMSO: 2 mg/mL, clear
storage temp.2-8°C
DOCUMENTS
RANGE
ATTRIBUTES
Cas Number2041073-22-5
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