Biochem/physiol Actions
kcat/Km ~ 2 x 104 s-1M-1 for furin
Cell permeable: no
Reversible: no
Product does not compete with ATP.
Primary TargetFluorogenic substrate for furin
General description
A fluorogenic substrate for furin (kcat/Km ~2 X 104 M-1 s-1), a mammalian homolog of the yeast Kex2 endoprotease. Also serves as a substrate for related protein, prohormone convertase 2 (PC2) (kcat/Km ~6 X 103 M-1 s-1). Excitation max: ~360-380 nm; emission max: ~430-460 nm).
A fluorogenic substrate for furin, a mammalian homolog of the yeast Kex2 endoprotease (kcat/Km ~ 2 x 104 s-1M-1).
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
Lamango, N.S., et al. 1996. Arch. Biochem. Biophys.330, 238.Hatsuzawa, K., et al. 1992. J. Biol. Chem. 267, 16094.
Packaging
5 mg in Plastic ampoule
Physical form
Supplied as a trifluoroacetate salt.
Reconstitution
Following reconstitution, aliquot and freeze (-20°). Stock solutions are stable for up to 3 months at -20°C.
Sequence
Pyr-Arg-Thr-Lys-Arg-AMC
Warning
Toxicity: Standard Handling (A)
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