Biochem/physiol Actions

Cell permeable: no

Reversible: no

Primary TargetSelective peroxynitrite scavenger

Product does not compete with ATP.

EC50 = 5 µM for cytoprotection against peroxynitrite

General description

A ferric porphyrin complex that catalytically isomerizes peroxynitrite to nitrate both in vivo and in vitro. Hence, serves as a selective peroxynitrite scavenger and decomposition catalyst. Provides cytoprotection against peroxynitrite (EC₅₀ = 5 µM). Does not complex with nitric oxide and exhibits minimal SOD mimetic activity.

A ferric porphyrin complex that catalytically isomerizes peroxynitrite to nitrate both in vivo and in vitro. Provides cytoprotection against peroxynitrite (EC₅₀ = 5 µM). Does not complex with nitric oxide and exhibits minimal SOD mimetic activity.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Imam, S.Z., et al. 2000. Ann. N.Y. Acad. Sci.914, 157.Misko, T.P., et al. 1998. J. Biol. Chem. 273, 15646.

Packaging

Packaged under inert gas

25 mg in Plastic ampoule

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 weeks at -20°C.

Warning

Toxicity: Standard Handling (A)