Biochem/physiol Actions

Primary TargetPeroxynitrite (ONOO-)

Cell permeable: no

Reversible: no

Kcat = 2.2 x 106 M-1s-1 in catalyzing the isomerization of peroxynitrite (ONOO-) to nitrate (NO3-) under physiological conditions

Product does not compete with ATP.

General description

Catalyzes the isomerization of peroxynitrite (ONOO^-) to nitrate (NO₃^-) under physiological conditions and at realistic dose-derived concentrations (K_cat = 2.2 x 10⁶ M^-1s^-1). Effectively prevents the oxidation of lipid components by peroxynitrite. Also decomposes superoxide radicals (O₂ ) catalytically. Irradiation of the aqueous solution at 335 nm releases hydroxyl (OH ) radicals. FeTMPyP can also serve as a potential drug for reactive oxygen species (ROS) detoxification.

Catalyzes the isomerization of peroxynitrite (ONOO^–) to nitrate (NO₃^–) under physiological conditions and at realistic dose-derived concentrations (K_cat = 2.2 x 10⁶ M^-1s^-1). Effectively prevents the oxidation of lipid components by peroxynitrite. Also catalytically decomposes superoxide radicals (O₂^⋅). Irradiation of the aqueous solution at 335 nm releases hydroxyl (OH⋅) radicals. FeTMPyP can also serve as a potential for drug detoxification of reactive oxygen species (ROS).

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Lee, J., et al. 1998. J. Am. Chem. Soc. 120, 7493.Hunt, J.A., et al. 1997. Chem. Biol. 4, 845.Marla, S.S., et al. 1997. Proc. Natl. Acad. Sci. USA 94, 14243.Stern, M.K., et al. 1996. J. Am. Chem. Soc. 118, 8735.Faraggi, M., et al. 1984. Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med.46, 703.

Packaging

10 mg in Plastic ampoule

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.

Warning

Toxicity: Standard Handling (A)